Method and composition for the treatment of lung surfactant deficiency or dysfunction
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United States of America Patent
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Apr 10, 2007
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app pub date -
Mar 14, 2005
filing date -
Apr 20, 2004
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Abstract
A method of treating a disease involving surfactant deficiency or dysfunction in a patient's lungs is disclosed comprising the steps of providing a liquid lung surfactant composition; aerosolizing the lung surfactant composition with a vibrating aperture-type aerosol generator to form a surfactant aerosol; and introducing the surfactant aerosol into the gas flow within a circuit of a pressure-assisted breathing system coupled to the patient's respiratory system, whereby a therapeutically effective amount of said surfactant is delivered to the patient's lungs. Apparatus is also disclosed that increases the efficiency of delivery of aerosolized medicaments such as aerosolized lung surfactant.
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