Importance

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Abstract

An ultrasound contrast agent precursor composition comprising: a plurality of void containing polymeric structures; a fluorocarbon gas osmotic agent having a water solubility of not more than about 0.5 mM at 25.degree. C. and one atmosphere; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form microbubbles upon addition of said microbubble precursor composition to an aqueous medium. An ultrasound contrast agent precursor composition comprising: lyophilized void containing structures; a perfluorocarbon gas osmotic agent, said gas osmotic agent dispersed in said voids; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form an ultrasound contrast agent upon addition of an aqueous liquid. An ultrasound contrast agent precursor composition comprising: spray dryed void containing structures; a perfluorocarbon gas osmotic agent, said gas osmotic agent dispersed in said voids; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form an ultrasound contrast agent upon addition of an aqueous liquid. An ultrasound contrast agent comprising a plurality of microbubbles comprising a phospholipid further comprising a perfluorocarbon gas osmotic agent.

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First Claim