Biodegradable crosslinking strategies using triglycidyl amine (TGA)
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United States of America Patent
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Issued Date -
Nov 3, 2005
app pub date -
Apr 29, 2005
filing date -
Apr 29, 2004
priority date (Note) -
Abandoned
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Abstract
The invention relates to implantable biodegradable bioprostheses and methods for making and using the bioprostheses. The implantable biodegradable bioprosthesis includes biomolecules having a reactive moiety and optionally a reactive group; and a biodegradable cross-linking moiety having (a) at least two linking moieties, wherein the at least two linking moieties are non-biodegradable and (b) a spacer, wherein the spacer is biodegradable and is in communication with the at least two linking moieties, provided that the biodegradable cross-linking moiety is artificial and is covalently bound to the reactive moiety. The implantable bioprosthesis is adapted to sufficiently degrade upon exposure to a cell or an enzyme to permit an expansion of the implantable bioprosthesis.
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