Reducing the risk of human anti-human antibodies through V gene manipulation
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United States of America Patent
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Issued Date -
Nov 24, 2005
app pub date -
Mar 17, 2005
filing date -
Mar 19, 2004
priority date (Note) -
Abandoned
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Abstract
The present embodiments relate to methods of identifying and creating human, or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included.
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