Implantable medical devices with antimicrobial and biodegradable matrices
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United States of America Patent
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Sep 14, 2010
Grant Date -
Dec 22, 2005
app pub date -
Jun 22, 2004
filing date -
Jun 22, 2004
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A composite vascular graft is provided, which incorporates bioactive agents that can be controllably delivered to the implantation site to deliver therapeutic materials and/or to reduce infection of the implant. The vascular graft of the present invention includes a luminal layer of ePTFE; and a biodegradable polymer layer including a bioactive agent, such as an antimicrobial agent. The biodegradable polymer layer is posited on the external surface of the luminal ePTFE layer. The graft also includes a fabric layer, which is posited on the external surface of the biodegradable layer. The graft is particularly useful as an arterial-venous graft for hemodialysis procedures.
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