Chronotherapeutic compositions and methods of their use
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United States of America Patent
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Issued Date -
Jan 5, 2006
app pub date -
Feb 10, 2005
filing date -
Feb 11, 2004
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Chronotherapeutic formulations of cardiovascular drugs are disclosed. The formulations comprise at least one cardiovascular drug that exhibits an in vivo elimination half-life of less than about 8 hours; wherein the formulation exhibits the following in vivo profile following administration to a subject: a) a delay in release of therapeutic levels of the at least one drug for about 2 to about 8 hours; b) a T.sub.max at about 8 to about 12 hours; c) a drug plasma level within 50% of the peak for greater than or equal to 12 hours; and d) a peak-to-trough ratio of drug plasma levels greater than or equal to about 4.
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