Method for preparing therapeutic ophthalmic articles using compressed fluids

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United States of America Patent

APP PUB NO 20060008506A1
SERIAL NO

11167083

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention describes a method for the impregnation of a drug or a drug composition into ophthalmic articles, in order to prepare drug sustained release systems mainly for the treatment of glaucoma and other eye diseases. Ophthalmic articles can be for example contact lenses. The drug or drug composition is dissolved in a compressed fluid, or mixture of compressed fluids, in a liquid, sub-critical liquid, gaseous or supercritical state. Co-solvents can be added to increase drug solubility in the compressed fluids. The mixture is subsequently contacted with the ophthalmic article. This process can be done in a single step or in a double step manner. The impregnation can be carried out in finished or semi-finished ophthalmic articles.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICAAPARTADO 12 QUINTA DO MARQUES P-2781-901 OEIRAS
UNIVERSIDADE DE COIMBRAPAÇO DAS ESCOLAS COIMBRA 3004-531

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baptista, Leite Eugenio Oscar Coimbra, PT 1 25
Cipriano, De Sousa Herminio Jose Coimbra, PT 1 25
Cruz, Duarte Ana Rita Estoril, PT 5 27
Martins, Duarte Catarina Maria Setubal, PT 2 29
Mendes, Gil Maria Helena Coimbra, PT 2 31

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