Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
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United States of America Patent
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Issued Date -
Jan 19, 2006
app pub date -
Jun 16, 2005
filing date -
May 17, 2002
priority date (Note) -
Abandoned
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Abstract
A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed, both phases are frozen, then the aqueous and nonaqueous frozen phases are removed by sublimation. The resulting porous microparticles can receive a gas and be used as an ultrasound contrast agent.
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