Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases
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United States of America Patent
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Issued Date -
Feb 2, 2006
app pub date -
Apr 12, 2005
filing date -
Oct 2, 2002
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Abandoned
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Abstract
Disclosed herein are methods for creating and using mutein proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using wild-type and mutein granzyme B to target VEGFR proteins to treat diseases, such as cancer. Cleaving VEGFR at certain substrate sequences with wild-type and mutein granzyme B proteases is a method for treating pathologies associated with angiogenesis.
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