Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
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United States of America Patent
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Issued Date -
Feb 2, 2006
app pub date -
Mar 7, 2005
filing date -
Jul 1, 2003
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Abandoned
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Abstract
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.
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