Pharmaceutically active lipid based formulation of irinotecan
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United States of America Patent
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Issued Date -
Feb 9, 2006
app pub date -
Jul 8, 2005
filing date -
Aug 20, 2002
priority date (Note) -
Abandoned
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Abstract
Delivering therapeutic amounts of irinotecan remains limited due to its highly water insoluble properties. This invention overcomes this limitation by presenting a novel method of preparing liposomal irinotecan by first inactivating irinotecan prior to liposome formation and then subsequently activating the irinotecan by lowering the pH of the lipid composition to an acidic pH of less than about 3.5, such as between 1.5-3.0 or about 2.
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