Cross-beta structure comprising amyloid-binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity
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app pub date -
Jan 10, 2005
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Jul 9, 2002
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Abstract
The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-.beta. structures and the biological role of these cross-.beta. structures. In one embodiment, the invention discloses a method for modulating extracellular protein degradation and/or protein clearance comprising modulating cross-.beta.(beta) structure formation (and/or cross-.beta. structure-mediated activity) of the protein present in the circulation.
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