Crystal of bacterial core RNA polymerase and methods of use thereof
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United States of America Patent
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app pub date -
Mar 28, 2005
filing date -
Sep 15, 1999
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Abstract
A detailed three-dimensional structure for a bacterial core RNA polymerase is provided. Crystals of the bacterial core RNA polymerase are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
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