Therapeutic calcium phosphate particles for use in inhibiting expression of a gene
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United States of America Patent
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app pub date -
Aug 2, 2005
filing date -
Feb 27, 2001
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Abstract
Novel calcium phosphate core particles, methods of making them, and methods of using them as carriers of biologically active material and controlled release matrices for biologically active material are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as polynucleotide material partially coating the particle or impregnated therein or both. The particles may be used to carry polynucleotide (or oligonucleotide) material that is complementary to a sequence of mRNA that binds to or ligates with and inhibits the expression of particular genes (by blocking translation of the mRNA sequence). The core particles are substantially spherical in shape, and have a substantially smooth surface.
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