Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering
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United States of America Patent
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Issued Date -
Apr 20, 2006
app pub date -
Oct 17, 2005
filing date -
Oct 15, 2004
priority date (Note) -
Abandoned
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Abstract
In one aspect, the invention relates to a synthetic conduit comprising a substantially tubular body comprising substantially circumferential polymer fibers; wherein the body has an exterior surface, an interior surface, and a lumen extending therethrough; and wherein the body has microscale features disposed at the interior surface. In a further aspect, cells can be optionally adhered to the exterior and/or interior surface of the substantially tubular body. In various aspects, the conduit can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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