Immunoglobulin construct containing tumor- specific p53bp2 sequenes for eliciting an anti-tumor response
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United States of America Patent
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Issued Date -
May 11, 2006
app pub date -
Apr 1, 2002
filing date -
Mar 30, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides immunoglobulins specific for p53BP2 ligand polypeptides. In a preferred embodiment, the present invention provides a variant of an immunoglobulin variable domain, wherein the immunoglobulin variable domain contains (A) at least one CDR region and (B) framework regions flanking the CDR, and the variant includes: (a) the CDR region having added or substituted therein at least one binding sequence, and (b) the flaking framework regions, wherein the binding sequence is heterologous to the CDR and the binding sequence is derived from a human ligand having immunogenic properties relevant to human lung cancer. In a preferred embodiment, the binding sequence is an antigenic sequence. In a further preferred embodiment, the variant contains a variable domain lacking an intrachain disulfide bond.
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