Methods and compositions for improving recombinant protein production
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United States of America Patent
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Oct 5, 2010
Grant Date -
May 11, 2006
app pub date -
Oct 5, 2005
filing date -
Oct 5, 2004
priority date (Note) -
Expired
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Abstract
Nucleic acid molecules modified to enhance recombinant protein, e.g., antibody, expression and/or reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing proteins devoid of mis-spliced and/or intron read-through by-products by the use of such vectors in host cells under cell culture conditions suitable for recombinant protein expression.
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