Synthesis of nanocodes, and imaging using scanning probe microscopy

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United States of America Patent

APP PUB NO 20060100787A1
SERIAL NO

10985547

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods for making nanocodes that can be detected using scanning probe microscopy are provided, as are nanocodes constructed of two or more polymers, including homogeneous polymers such as nucleic acid molecules and heterogeneous polymers such as peptide nucleic acid polymers, and subunits useful for constructing such nanocodes. Also provided are modified nanocodes such as a nanocode containing one or more linked metals such as gold or iron and/or a linked probe that can specifically bind a target molecule. In addition, systems are provided that include such nanocodes, for example, a system that includes the nanocode and a surface and/or a scanning probe microscope probe. Methods of using such nanocodes, for example, to detect and/or identify a target molecule in a sample (e.g., a biological or environmental sample) using scanning probe microscopy, also are provided.

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Patent Owner(s)

Patent OwnerAddress
CALLIDA GENOMICS INC670 ALMANOR AVENUE SUNNYVALE CA 94085

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berlin, Andrew A San Jose, CA 102 4215
Kosmoski, Joseph V Cathedral City, CA 6 322
Su, Xing Cupertino, CA 190 4986
Sundararajan, Narayanan San Francisco, CA 32 972
Yamakawa, Mineo Campbell, CA 93 2069

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