Novel epithelial tissue imaging agent
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United States of America Patent
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Issued Date -
May 18, 2006
app pub date -
Jan 4, 2006
filing date -
Jan 10, 1997
priority date (Note) -
Abandoned
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Abstract
Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having .beta.-sheet character, each of the domains being separated by domains lacking .beta.-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.
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