Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
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United States of America Patent
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Issued Date -
May 18, 2006
app pub date -
Aug 15, 2005
filing date -
Aug 16, 2004
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, the presence, amount, or enzymatic activity of glutathione peroxidase-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information. While applicable to diseases and conditions in which inflammation is generally manifested, the methods and compositions described herein are particularly applicable to acute coronary syndromes, including conditions selected from the group consisting of unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
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