Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin
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United States of America Patent
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Mar 22, 2011
Grant Date -
May 25, 2006
app pub date -
Apr 7, 2003
filing date -
Apr 9, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to liquid pharmaceutical formulations for oral administration with the modified release of amoxicillin, said formulations consisting of suspensions of coated particles of amoxicillin (microcapsules). According to the invention, the microcapsules constituting the disperse phase of the suspension are designed to allow the modified release of the amoxicillin according to a profile that does not change during the storage of the liquid suspension. To do this the inventors propose the selection of a specific coating composition for the microcapsules which consists of at least four components that allow these microcapsules to be stored in water without modifying their properties of modified release of the amoxicillin, this liquid phase furthermore being saturated with amoxicillin.
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