Method of modulating cellular activity and molecules for use therein
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United States of America Patent
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Issued Date -
Jun 8, 2006
app pub date -
Sep 4, 2003
filing date -
Sep 4, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to a method of modulating T cell functional activity by utilising .beta.-amino acid substituted peptides and to agents useful for the same. More particularly, the present invention relates to a method of modulating class I restricted T cell activity by utilising .beta.-amino acid substituted peptides and to agents useful for the same. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by suboptimal T cell stimulation such as that which occurs in some viral infections and in anti-tumour immunity, as well as aberrant, unwanted or otherwise inappropriate T cell functioning such as, but not limited to, graft rejection or autoimmune conditions, the present invention is further directed to methods of identifying, designing and/or modifying agents capable of modulating T cell functional activity.
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