Compositions and methods for treating pathologies that necessitate suppression of gastric acid secretion

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United States of America Patent

SERIAL NO

11351001

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Abstract

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The present invention is related to novel oral compositions comprising an irreversible gastric H.sup.+/K.sup.+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion.

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Patent Owner(s)

Patent OwnerAddress
VECTA LTDRA'ANNANA 43662

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
David, Ayelet Negev, IL 9 68
Glozman, Sabina Rehovot, IL 19 178
Paul, Lada Vancouver, CA 1 7

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