Polynucleotide delivery to cardiac tissue
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United States of America Patent
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app pub date -
Aug 25, 2005
filing date -
Feb 26, 2004
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Abstract
A method for delivering a polynucleotide to cardiac tissue, including substantially isolating the coronary venous circulation from systemic circulation, and introducing a polynucleotide into the isolated coronary venous circulation to effect localized transfection of cardiac tissue. The polynucleotide advantageously produces a therapeutic effect, such as increasing or decreasing the expression level of a protein in the cardiac tissue.
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