Variably crosslinked tissue
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United States of America Patent
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Apr 5, 2011
Issued Date -
N/A
app pub date -
Feb 27, 2006
filing date -
Jan 25, 2002
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Abstract
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.
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