Genetically modified tumor cells as cancer vaccines
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United States of America Patent
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Issued Date -
Jul 27, 2006
app pub date -
Dec 9, 2005
filing date -
Dec 10, 2004
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides methods and compositions for electroporation-mediated gene transfer to cancer cells. The transfected cancer cells are genetically modified to express one or more therapeutic proteins. In certain embodiments, the cancer cells are modified to express one or more cytokines capable of enhancing the immunogenicity of the transfected cancer cell. Administering the transfected cancer cell to a subject will lead to enhanced immune-cell mediated killing of tumors. Accordingly, the present invention provides methods and compositions for improved treatment and prevention of cancer and other hyperproliferative diseases.
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