Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
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United States of America Patent
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Jan 27, 2009
Grant Date -
Aug 3, 2006
app pub date -
Jan 28, 2005
filing date -
Jan 28, 2005
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Abstract
The invention provides methods and compositions for improving the fidelity of a sequencing-by-synthesis reaction by using a nucleotide derivative that forms a hydrogen bond with a complementary nucleotide on a template, but fails to form a phosphodiester bond with the 3′ hydroxyl group of a primer under conditions otherwise suitable for a polymerization reaction; thereby blocking incorporation of a mismatched nucleotide.
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