Novel beta-secretase and modulation of beta-secretase activity

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United States of America Patent

SERIAL NO

11403512

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Abstract

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The invention concerns a novel .beta.-secretase, a method of partially purifying this novel .beta.-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel .beta.-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

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Patent Owner(s)

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SCIOS INC6500 PASEO PADRE PARKWAY FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cordell, Barbara Palo Alto, CA 35 810
Hyslop, Paul Andrew Indianapolis, IN 6 18
Johnstone, Edward Marion Indianapolis, IN 3 9
Little, Sheila Parks Indianapolis, IN 3 9
Liu, Yu-Wang Santa Clara, CA 7 108
Queener, Stephen Wyatt Indianapolis, IN 2 4
Quon, Diana Hom Redwood City, CA 6 116
Schimmoller, Frauke Menlo Park, CA 11 207
Xu, Qiang Cupertino, CA 173 891
Yin, Tinggui Indianapolis, IN 3 9
Zhong, Ziyang Union City, CA 23 69

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