Topical management of ocular and periocular conditions
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United States of America Patent
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Issued Date -
Aug 24, 2006
app pub date -
Jan 13, 2006
filing date -
Jan 13, 2005
priority date (Note) -
Abandoned
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Abstract
Chronic glaucoma, cataract, ocular and periocular aging are treated and prevented by the administration of agents that affect metabolic subsystems such as (i) mitochondrial bioenergetics, (ii) free radical moderation and glutathione maintenance, (iii) constitutive nitric oxide/endothelin-1 balance, and (iv) calcium wave signaling and associated neuronal excito-toxicity. Included among the agents are tetrahydrobiopterin, R-alpha-lipoic acid, coenzyme Q10, 17 alpha-estradiol, and glutathione.
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