Porphyrin-based compounds for tumor imaging and photodynamic therapy
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United States of America Patent
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Issued Date -
Sep 7, 2006
app pub date -
Feb 14, 2006
filing date -
Feb 25, 2005
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Abandoned
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Abstract
This invention describes a first report on the synthesis of certain .sup.124I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
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