Use of prostate specific antigen to predict drug response

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20060199230A1
SERIAL NO

11072854

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of determining the likelihood for a subject to respond to a drug, comprising: measuring at least one PSA-related value in a subject suffering from a PSA-related disorder and having been administered a drug for treating the PSA-related disorder; comparing the PSA-related value with its respective control value; and determining the likelihood for the subject to respond to the drug, wherein the PSA-related value is selected from the group consisting of the amount of BPSA, the amount of proPSA, the ratio of BPSA to proPSA, the ratio of BPSA to total PSA, the ratio of BPSA to free PSA, and a combination thereof; and wherein the amount of BPSA, the ratio of BPSA to proPSA, the ratio of BPSA to total PSA or the ratio of BPSA to free PSA, if higher than its respective control value by a respective first predetermined value; the amount of proPSA, if lower than its respective control value by a second predetermined value; or a combination thereof; indicates that the subject is likely responsive to the drug. Also disclosed is a kit for using such a method to predict whether a subject would be a drug responder.

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Patent Owner(s)

Patent OwnerAddress
HYBRITECH INCORPORATED11095 TORREYANA ROAD SAN DIEGO CA 92121-1197

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mikolajczyk, Stephen D San Diego, CA 21 115

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