Use of methyltransferase inhibitors to enhance transgene expression
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United States of America Patent
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Issued Date -
Sep 14, 2006
app pub date -
Feb 17, 2006
filing date -
Feb 18, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention concerns enhancing transgene expression in electroporated cells. Electroporation-mediated transfection of cells has several advantages over other transfection methods. However, the efficiency of transgene expression in electroporated cells may be lower than desired for certain applications. The ability to further enhance transgene expression in electroporated cells would be useful in a number of applications including protein and virus production. The present invention provides a method for enhancing transgene expression in a cell, the method comprising transfecting the cell by electroporation with an expression construct encoding a protein; and contacting the cell with a methyltransferase inhibitor, wherein the expression of the protein is enhanced as compared to the expression of the protein in a second cell not contacted with the methyltransferase inhibitor.
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