Use of apotosis inhibiting compounds in degenerative neurological disorders
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United States of America Patent
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Sep 13, 2011
Grant Date -
Sep 21, 2006
app pub date -
Oct 21, 2005
filing date -
Oct 22, 2004
priority date (Note) -
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Abstract
The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region.
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