Stabilized liquid polypeptide formulations
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United States of America Patent
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Issued Date -
Sep 21, 2006
app pub date -
Jan 27, 2006
filing date -
Jan 28, 2005
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides formulations for maintaining the stability of polypeptides, in particular, therapeutic antigen-binding polypeptides such as antibodies and the like, for example, anti-A.beta. antibodies. The formulations generally include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine, and thus, the formulations are suitable for several different routes of administration.
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