Methods and compositions for assay readouts on multiple analytical platforms
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United States of America Patent
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Issued Date -
Sep 21, 2006
app pub date -
Mar 16, 2006
filing date -
Mar 16, 2005
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Abstract
The invention provides methods and compositions for reading out the results of multiplex assays on various analytical platforms, such as microarrays, bead arrays, electrophoresis devices, and the like. An important feature of the invention includes methods for converting different sets of oligonucleotide tags used for labeling into oligonucleotide tags specific for a particular analytical platform. The invention further includes compositions comprising oligonucleotide tags having convenient properties for labeling and conversion, particularly ligation tags that employ ligation reaction specificity as well as sequence specificity in order to discriminate between tags.
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