Importance

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Abstract

A formulation and method for the preparation of topical anesthetics formulations, containing one or more anesthetics, in a delivery vehicle designed to promote penetration of the anesthetics into the skin and underlying tissue and to facilitate the speed of action and prolonged response. The stratum corneum layer of the skin at the application site is at least partially removed by an abrading substance, such as pumice, preferably incorporated into the formulation, or by a step that uses a mechanical abrasion of the outer layer of skin, such as a rotating or vibrating brush. The enhanced penetration into the live skin tissue is achieved by removing the outer layer of stratum corneum skin tissue by including an abrading substance in a formulation containing the anesthetics, then rubbing the formulation into the skin, or the use of a brush-like device to assist in the removal of the skin layer.

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First Claim