Drug-Delivery Endovascular Stent and Method for Treating Restenosis
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United States of America Patent
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app pub date -
Jun 9, 2006
filing date -
Nov 5, 2001
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Abstract
An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 80 weight percent of a polymer substrate and (ii) 20-90 weight percent of an anti-restenosis compound.
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