Enduring T cell response
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United States of America Patent
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Issued Date -
Oct 19, 2006
app pub date -
Feb 5, 2004
filing date -
Feb 6, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides a trimeric polypeptide construct, wherein each monomer of the trimeric polypeptide construct consists of two or three domains, and wherein the first domain is the extracellular domain of 4-1BBL or (a) part(s) thereof, the second domain consists of an antigen-interaction-site which is located N-terminally of the first domain and, optionally, the third domain combines said first and second domain via a peptide linker, wherein said peptide linker does not comprise any polymerization activity. Further, the invention provides nucleic acid molecules encoding said polypeptide constructs, vectors and hast systems for the expression of the trimeric polypeptide construct. Moreover, the invention provides compositions which are envisaged to be pharmaceutical compositions and their use in the treatment of diseases.
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