Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
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United States of America Patent
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Issued Date -
Oct 26, 2006
app pub date -
Dec 15, 2005
filing date -
Dec 15, 2004
priority date (Note) -
Abandoned
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Abstract
In various aspects, the present invention provides methods and kits for predicting the therapeutic efficacy of an immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder by comparing the amount of A.beta. monomer in an A.beta. preparation which binds to the immunological reagent to an amount of one or more A.beta. oligomers in the A.beta. preparation which bind to the immunological reagent to determine a relative bound amount, and predicting the efficacy of the immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder based at least on the relative bound amount.
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