Optically active (R)-hydantoin derivative
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United States of America Patent
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Issued Date -
Oct 26, 2006
app pub date -
Apr 20, 2005
filing date -
Apr 20, 2005
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Abandoned
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Abstract
(R)-(+)-5-hydroxy-1-methylhydantoin is an optically active substance having an excellent suppressive action of the progression of renal failure. At an administration to a model animal of renal failure, (R)-(+)-5-hydroxy-1-methylhydantoin significantly suppresses an increase of creatinine in blood as compared with the S-form and the racemate, and shows an excellent suppressive action to the progression of renal failure by improving creatinine clearance. Thus, (R)-(+)-5-hydroxy-1-methylhydantoin is useful as a highly-active agent for renal failure.
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