Localized delivery of nucleic acid by polyelectrolyte assemblies
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United States of America Patent
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May 27, 2014
Grant Date -
Nov 9, 2006
app pub date -
May 1, 2006
filing date -
Apr 29, 2005
priority date (Note) -
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Abstract
The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention.
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