Method for preparing 3'-amino-2',3'-dideoxyguanosine
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United States of America Patent
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Issued Date -
Nov 23, 2006
app pub date -
Apr 27, 2006
filing date -
Apr 28, 2005
priority date (Note) -
Abandoned
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Abstract
Disclosed therein is a method for preparing the 3'-amino-2',3'-dideoxyguanosine, comprising the steps of: (a) treating 3'-amino-3'-deoxythymidine and 2,6-diaminopurine with a pyrimidine nucleoside phosphorylase and a purine nucleoside phosphorylase to prepare 3'-amino-2',3'-dideoxyribosyl 2,6-diaminopurine; and (b) converting enzymatically the 3'-amino-2',3'-dideoxyribosyl 2,6-diaminopurine with an adenosine deaminase to prepare 3'-amino-2',3'-dideoxyguanosine. According to the present invention, 3'-amino-2',3'-dideoxyguanosine may be obtained with very high yield in a relatively simple procedure.
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