Novel process for preparation of isotonic aqueous injection of ropivacaine
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United States of America Patent
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Issued Date -
Nov 30, 2006
app pub date -
May 25, 2005
filing date -
May 25, 2005
priority date (Note) -
Abandoned
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Abstract
The preparation of an injectable solution of ropivacaine by dissolving ropivacaine base in aqueous acidic solution having a molar ratio of acid to ropivacaine base greater than 1:1 eliminates the need for a hydrochloride or hydrochloride monohydrate intermediate in the manufacture of the injectable. The osmolality can be adjusted as needed. The excess acid is neutralized with a base.
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