Methods for treating functional bowel disorders using alpha2 subunit calcium channel modulators with smooth muscle modulators
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United States of America Patent
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Issued Date -
Dec 7, 2006
app pub date -
Mar 22, 2004
filing date -
Jul 10, 2003
priority date (Note) -
Abandoned
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Abstract
A method is provided for using .alpha..sub.2.delta. subunit calcium channel modulators or other compounds that interact with the .alpha..sub.2.delta. calcium channel subunit in combination with one or, more compounds with smooth muscle modulatory effects to treat functional bowel disorders in patients in need of treatment. According to the present invention, .alpha..sub.2.delta. subunit calcium channel modulators include GABA analogs including gabapentin and pregabalin, fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, .beta.3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
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