Methods for immunotherapy of cancer
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Dec 21, 2006
app pub date -
May 26, 2006
filing date -
May 31, 2005
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Provided are methods of generating an immune response to an antigen specifically associated with tumor vascular endothelial cells (TVECA). The method comprises administering to an individual an expression vector encoding the TVECA. The vector comprises a transcription unit encoding a secretable fusion protein, the fusion protein containing a TVECA and CD40 ligand. In other methods, administration of a fusion protein containing the TVECA and CD40 ligand is used to enhance the immune response above that obtained by vector administration alone. Further methods comprise the combination therapy using an expression vector encoding a secretable TVECA fusion protein and a tumor antigen vaccine.
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