Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
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United States of America Patent
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Aug 28, 2012
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app pub date -
Jun 16, 2006
filing date -
Jun 16, 2005
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Abstract
The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.
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