Compositions comprising fenofibrate and atorvastatin
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United States of America Patent
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app pub date -
Nov 15, 2004
filing date -
Oct 10, 2003
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Abstract
The present invention relates to pharmaceutical compositions in particulate form or in solid dosage forms comprising a combination of fenofibrate and the HMG CoA reductase inhibitor atorvastatin or a pharmaceutically active salt thereof, which upon oral administration provides a relative AUC.sub.0-24 value (AUC.sub.fibric acid/AUC.sub.atorvastatin) of between about 250 and about 10,000. The solid compositions are manufactured without any need of addition of water or aqueous medium and comprise at least 80% of the active substances fenofibrate and atorvastatin in dissolved form, or, optionally, atorvastatin in micronized form, in order to ensure suitable bioavailability.
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