Drug formulation containing a solubilizer for enhancing solubility, absorption, and permeability

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United States of America Patent

APP PUB NO 20070021325A1
SERIAL NO

11188217

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Abstract

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Solubility, absorption, and permeability of drugs upon oral administration are improved when the drugs are mixed and/or complexed with water-miscible organic solvents. Illustratively, the absorption of a heparin-deoxycholic acid conjugate upon oral administration is increased by mixing and/or complexing this conjugate with dimethyl sulfoxide. Other illustrative water-miscible organic solvents include N-methylpyrrolidone, polyoxyl 35 castor oil, diethylene glycol monoethyl ether, and benzoic acid.

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Patent Owner(s)

Patent OwnerAddress
MEDIPLEX CORPORATION KOREA2703 TRADE TOWER 159-1 SAMSUNG-DONG KANGNAMKU SEOUL 135-729

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Byun, Youngro Seoul, KR 21 439
Kim, Sang Kyoon Seoul, KR 4 57

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