Long-acting derivatives of pyy agonists
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United States of America Patent
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Issued Date -
Feb 1, 2007
app pub date -
Apr 8, 2004
filing date -
Apr 8, 2003
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Abstract
The invention provides a PYY agonist derivative of the formula: (X).sub.n-Z, wherein X is a radical 9-fluorenylmethoxy-carbonyl (Fmoc) or 2-sulfo-9-fluorenyl-methoxycarbonyl (FMS), Z is the residue of a PYY agonist linked to the radical X through an amino or hydroxyl group, and n is 1 to 3, or a pharmaceutically acceptable salt thereof, for reducing food intake and treatment of a disease, condition or disorder that can be alleviated by reduction of food intake such as obesity, hypertension, dyslipidemia, cardiovascular risk, eating disorder, insulin-resistance, or diabetes mellitus.
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