Semi-synthetic conversion of paclitaxel to docetaxel
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United States of America Patent
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Issued Date -
Feb 1, 2007
app pub date -
Mar 16, 2006
filing date -
Jun 29, 2004
priority date (Note) -
Abandoned
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Abstract
A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2', C-7 and C-10 and introducing a t-Boc group at the nitrogen of the amide group at the C-3' position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.
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